Glenmark nasal spray cuts down viral load of Covid by 94% in 24 hrs
Glenmark’s nitric oxide nasal spray (NONS), which it sells under the brand FabiSpray in India, reduces the viral load of Sars-CoV-2 in high-risk adult Covid-19 patients by 94 per cent within 24 hours and 99 per cent in 48 hours, according to the results of phase 3 trial of the drug published in The Lancet Regional Health Southeast Asia journal.
Glenmark had conducted the study on 306 vaccinated and unvaccinated adults with symptomatic mild Covid-19 disease across 20 clinical trial sites in India. The trial evaluated a seven-day treatment of NONS, plus the standard of care versus placebo nasal spray and standard of care in patients. NONS was administered six times daily as two sprays per nostril for seven days.
“Use of NONS in patients recently infected with SARS-CoV-2 accelerates nasal virus clearance,” the study published in The Lancet said. It said the high-risk population (unvaccinated or over 45 years of age, or with one or more comorbidities) demonstrated a ‘profound’ Sars-CoV-2 RNA burden reduction of 93.7 per cent at 24 hours and 99 per cent at 48 hours with NONS.
“NONS had a rapid effect of viral RNA reduction, i.e., a 7⋅4 fold greater viral RNA reduction compared to placebo at 48 hours of treatment,” the study showed.
Glenmark has tied up with Canadian biotech firm SaNOtize to manufacture, market, and distribute its NONS for Covid-19 treatment in India and other Asian markets. Glenn Saldanha, managing director and chief executive of Glenmark, had told Business Standard last year that a major clinical trial by SaNOtize was being conducted in Canada over 4,000 people to see if the drug also works in prevention of Covid-19.
It launched the nasal spray in India this February after the drug regulator gave nod to its launch after a local clinical trial.
NONS is designed to kill coronavirus in the upper airways, preventing it from incubating and spreading to the lungs. “It is based on nitric oxide, a natural nanomolecule with proven anti-microbial properties, and which has a direct effect on SARS-CoV-2, the virus causing Covid-19,” a company spokesperson has said.
Business Standard has always strived hard to provide up-to-date information and commentary on developments that are of interest to you and have wider political and economic implications for the country and the world. Your encouragement and constant feedback on how to improve our offering have only made our resolve and commitment to these ideals stronger. Even during these difficult times arising out of Covid-19, we continue to remain committed to keeping you informed and updated with credible news, authoritative views and incisive commentary on topical issues of relevance.
We, however, have a request.
As we battle the economic impact of the pandemic, we need your support even more, so that we can continue to offer you more quality content. Our subscription model has seen an encouraging response from many of you, who have subscribed to our online content. More subscription to our online content can only help us achieve the goals of offering you even better and more relevant content. We believe in free, fair and credible journalism. Your support through more subscriptions can help us practise the journalism to which we are committed.
Support quality journalism and subscribe to Business Standard.
Comments are closed.